The debate of the value of plasma lipids as predictive risk factor for atherogenesis has centered for many years on cholesterol, triglyceride and LDL (low density lipoprotein)
Lately, interest has focused on the role of HDL (high density lipoprotein) as an antirisk factor. So, HDL-cholesterol and/or apoprotein A have been estimated as an index of HDL level in clinical laboratory.
Recently, a possible role for apoprotein have been emphasized.
This study was performed to investigate the relationship between serum lipids and hypertension.
Serum lipids such as triglyceride, cholesterol, phospholipid, lipoprtein fraction, HDLcholesterol, and apoprotein A-I were measured in 87 patients with hypertension.
The results obtained were as follows;
1. The mean levels of serum lipids in hypertensive patients were 162.0±114.0 mg/dl for cholesterol, 208.1±74.7 mg/dl for phospholipid, and the lipoprotein fraction revealed 31.9±8.3% of a-lipoprotein, 25.8±10.4% of pre (3-lipoprotein and 42.4±8.8% of 1i-lipoprotein. The levels of serum triglyceride, phospholipid and pre 1i-lipoprotein were significantly increased in hypertersive patients than in normal control groups.
2. The mean levels of serum HDL-cholesterol and Apoproteins A-I in hypertensive patients were 40.2±12.5 mg/dl, 134.1±41.2 mg/dl, respectively, and both were significantly lower in hypertensive patients than in normal control group, particularily in 6th and 7th decade.
3. Only serum HDL-cholesterol and apoprotein A-I were significantly lower than in hypertensive patients with complication than in hypertensive patients without complication.
4. The level of serum triglyceride was significantly higher in hypertensive patients particularly complicated with diabetes mellitus, congestive heart failure and hepatopathy, while the level -of serum phospholipid was significantly lower in hypertensive patient than in normal control, particularly complicated with renal disease and cerebrovascular accidents.
5. The incidence of hyperlipidemia in hypertensive patients was 44.8%, and no significant difference was found between frequency of hyperlipidemia and degree of blood pressure.
6. The level of serum HDL-cholesterol, apoprotein A-I and molar ratio of HDL-cholesterol/ Apo A-I showed significant lower in hypertriglyceridemia.
7. Apo A-I was highly positively correlated with HDL-cholesterol in hypertensive patients.
8. Serum triglyceride and pre. (3-lipoprotein showed Inverse correlation with HDL-choles terol and a-lipoprotein showed positive correlation with HDL-cholesterol.
9. Serum a-lipoprotein showed positive correlation with apoprotein A-1 and (3-lipoprotein showed negative correlation with apoprotein A-I.
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